/tag/drug-discovery
In-Silico NCAA-Containing Peptide Design
Bacteria are an important type of human pathogen that can cause life-threatening infections. Increasingly, these microorganisms can survive the effects of antibiotics previously used to kill them. As bacteria become resistant to multiple kinds of antibiotics, the diseases they cause become ever more difficult to cure. Accordingly, infections caused by ‘multidrug-resistant’ (MDR) pathogens are associated with frequent treatment failures, high hospitalization costs, and substantial mortality. New therapeutics are needed to treat infections caused by MDR bacteria. Towards developing these critical countermeasures, our group has discovered a unique peptide that efficiently kills many of the most challenging antibiotic-resistant pathogens and also demonstrates therapeutic efficacy in pre-clinical animal models of bacterial infection.
